Absolutely, B450 motherboards provide full support for M.2 NVMe SSDs, which bring about a considerable reduction in boot and load times, generally utilizing a PCIe 3.0 interface, however, there are some motherboards that impose restrictions like turning off some SATA ports or providing just one NVMe-capable slot (frequently the first one). With this configuration, you will experience the full benefit of PCIe Gen 3 NVMe drives, while, in case of PCIe Gen 4 NVMe SSDs, they will operate at Gen 3 speeds; it is advisable to perform a BIOS and chipset driver update for optimal compatibility.